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Introducing the First-Ever Immune Health Supplement with an NAD+ Boost

What is Tru Niagen?

TRU NIAGEN is a new cellular health vitamin produced by ChromaDex, a scientifically based corporation. ChromaDex is devoted to unlocking the full potential of Tru Niagen and understanding more about the tremendous effects it can have on cellular health, repair, and resilience by collaborating with some of the world’s finest experts.

Tru Niagen is nicotinamide riboside (Niagen®), a unique type of vitamin B3. Niagen® is a NAD+ precursor that serves as a building block for your body to produce NAD+. This is significant because NAD+ is a coenzyme that is essential for cellular health; however, NAD+ levels fall with aging and other physiological stresses such as poor food, alcohol, a lack of sleep, or too little or too much activity.Tru Niagen® has been clinically proved to assist your body in increasing NAD+ levels. Furthermore, Niagen® is the first and only patented and FDA-approved version of nicotinamide riboside.

Tru Niagen discount & Tru Niagen coupon code 

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Tru Niagen Products

Tru Niagen® 300mg

Tru Niagen 300 mg bottle in two sizes
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Tru Niagen® 300mg, a multi-award-winning supplement, feeds your cells with a single daily pill.

  • Healthy Aging: As you become older, your NAD+ levels naturally fall. Tru Niagen helps to preserve general health and well-being by supporting cellular function and metabolism.
  • Heart Health: For optimal operation, your heart requires a continual flow of energy. In addition to a healthy lifestyle, increasing NAD+ levels with Tru Niagen® can provide further support to one of your most important organs.
  • Muscle Health and Recovery: Staying active is essential for sustaining vitality, and supplying your muscle cells with more NAD+ promotes overall muscle health and recovery.
  • Tru Niagen provides cellular energy by fueling your body’s energy engines, the mitochondria.
  • Tru Niagen aids in the defense of cells against metabolic stressors such as inadequate nutrition.
  • Cellular Repair: Tru Niagen supports cellular repair, mitigating the effects of stress and time on your body.

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Tru Niagen® Immune

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Say welcome to the first-of-its-kind combination of proven immune-boosting nutrition and NAD+ support (from the proprietary flagship supernutrient Niagen®) for optimum aging cell maintenance and function.


  • VegD3® vegan vitamin D (2,000IU/50mcg | 250 percent DV), a highly bioavailable, algae-derived version of vitamin D3.
  • Natural vitamin C (180mg | 200 percent DV) produced from fermentation (as opposed to synthetically sourced).
  • Zinc (20mg | 182 percent DV) in two forms for improved absorption: gluconate and citrate.
  • With Theracurmin (30mg), the market’s most bioavailable form of curcumin (27x the bioavailability of other curcumin products).
  • Plus Niagen (150mg), our proprietary flagship supernutrient, for optimal cellular maintenance and performance.

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Tru Niagen® Stick Packs


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Learn about the advantages of cellular energy, defense, repair, and vitality. Combine 300mg of  Tru Niagen® suggested dosage with your favorite beverage.

  • Cellular Energy: Tru Niagen® provides energy to your body’s energy engines, the mitochondria.
  • Cellular Defense: Tru Niagen® aids in the defense of cells against metabolic stressors such as overeating.
  • Cellular Repair: Tru Niagen® supports cellular repair, mitigating the effects of stress and time on your body.
  • Cellular Vitality:Tru Niagen® promotes young cellular activity by assisting cells in running more effectively as you age.

Tru, Two-Way Immune Support

This is the market’s only immune health product that focuses NAD+ support. When you take it on a daily basis, you are providing your cells with the nutrition they require to build more energy from inside, as well as immune-boosting nutrients (plus curcumin for general vitality) from outside.

You may already be taking vitamin D, C, zinc, and curcumin on their own or as a supplement. You may now obtain highly absorbable versions of these nutrients, as well as a NAD+ boost, all in one easy pill.

Tru Niagen Immune: Daily immune system feeding and daily energy support for your 37.2 trillion cells.

A Truly Powerful Combination

Tru Niagen Immune was introduced as a companion product to Tru Niagen.

Take both for full immune support and daily NAD+ replenishment in whatever way works best for you—you can take your usual serving of the original product and Immune at the same time, or take them separately throughout the day. And, if you’re feeling very drained or unwell, it’s a good idea to take more Tru Niagen—safe it’s to take up to 2,000mg of Niagen each day.

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The science behind Tru Niagen

Your cells are the foundation of your health. Everything you accomplish in life is based on the ongoing cycle of utilizing and rebuilding energy in your cells. Scientists have known for decades that a coenzyme (a chemical that connects to proteins) called NAD+ (nicotinamide adenine dinucleotide) plays an important part in your body’s activities. NAD+ aids in the production of cellular energy and the repair of cells throughout your body’s trillions of cells and organs.

Your NAD+ supply decreases with age as well as in reaction to stresses on your body, such as alcohol intake, strenuous activity, and a lack of sleep. However, in 2004, Dr. Charles Brenner found nicotinamide riboside, a naturally occurring vitamin in milk. This vitamin boosts NAD+ levels by 40-50%.

While nicotinamide riboside can be found naturally in certain foods, a regular diet cannot provide anything near the quantity required to successfully boost NAD+. That is why we developed Tru Niagen®, the world’s only patented, extensively researched, and safety-tested nicotinamide riboside.

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Is Tru Niagen better than Nmn?Nicotinamide Riboside vs NMN

Niagen® (nicotinamide riboside) and NMN (nicotinamide mononucleotide) are two well-known NAD+ precursors, although NMN falls short as a safe and effective NAD+ supplement (nicotinamide adenine dinucleotide).

NAD+ has been at the forefront of studies on aging, health, and illness in recent years.

However, the prominence of NAD+ research has also led to misunderstanding concerning NAD+ and NAD+ precursors.

An NAD+ precursor, for example, is a “building block” for the cell to use in the production of NAD+. However, NMN is a precursor to nicotinamide riboside, which is then converted to NAD+. Given that nicotinamide riboside (NR) is more direct, this differential is critical in terms of efficiency.

So, who should you believe? The data strongly favors Niagen®, but here’s a breakdown to properly examine these NAD+ precursors.

Niagen® has a roughly 3 to 1 advantage over NMN in ongoing clinical trials

There are more than 45 active studies employing Niagen® compared to more than 15 for NMN, according to Clinicaltrials.gov, a government-sponsored database of human clinical trials, and the World Health Organization (WHO) International Clinical Trials Registry. That’s almost a three-to-one ratio.

These figures demonstrate the expanding body of study surrounding Niagen®, which is looking into the numerous health advantages of increasing NAD+ levels in people.

Niagen® has been the subject of 13 peer-reviewed human clinical trials. There are three at NMN

Niagen® has been studied in 13 human clinical trials, giving it a far broader and more persuasive scientific base as the recommended NAD+ booster.

NMN, on the other hand, has only been the topic of three peer-reviewed clinical investigations.

The First Human Research on NMN

The first human study, published in the Endocrine Journal in 2023, did not test the effect of NMN supplementation on NAD+ levels.

The study included 10 healthy Japanese male patients aged 40-60 in a small, non-blind, uncontrolled (no placebo) experiment. The NMN was provided during three visits, each more than a week apart, throughout the trial. The subjects were given a single dosage of NMN of 100, 250, or 500mg.

The study revealed that fairly high levels of NMN supplements had no major side effects and are tolerable. Nonetheless, it did not examine the effect on NAD+ levels or the safety of daily NMN administration over any substantial time period.

The Second Human Research on NMN

The findings of the second study, which was published in the journal Science, were better. In prediabetic women, NMN supplementation dramatically enhanced NAD+ levels as well as muscle insulin sensitivity and signaling.

However, one important weakness of this study is the researchers’ failure to adequately randomize the individuals.

Dr. Charles Brenner’s commentary emphasizes that the metabolic health of the placebo and NMN groups was substantially different. The placebo group’s average amount of liver fat was more than double that of the NMN group.

In experimental design, ensuring proper randomization of subjects eliminates inadvertent bias. In the case of NMN’s second human research, faulty randomization most certainly resulted in the NMN group overpromising improvement.

The Third Human Research on NMN

The third research, published in the Journal of the International Society of Sports Nutrition, did not assess the effect of NMN supplementation on NAD+ levels, but it did reveal a substantial improvement in aerobic capacity after exercise training in healthy amateur runners.

However, no changes in the individuals’ body mass or composition were seen in this NMN investigation. In contrast, NR enhances body fat-free mass and improves body composition in healthy overweight or obese men and women, according to a research published in The American Journal of Clinical Nutrition.

Niagen® has ten human clinical investigations that show it successfully boosts NAD+ levels. The NMN has one

To far, a collection of human clinical research has conclusively demonstrated that Niagen® efficiently and safely raises NAD+ levels. The continuous use of Niagen® in these trials demonstrates the scientific community’s confidence in the precursor. The majority of studies points to Niagen® as the best choice for a NAD+ precursor.

The First Human Niagen® Study to Show Effectiveness

A research published in Nature Communications in 2016 found that single oral dosages of Niagen® of 100mg, 300mg, and 1000mg can safely raise NAD+ levels. Researchers studied the effects of NR supplementation in 12 healthy men and women, determining its safety and effectiveness as a NAD+ supplement.

The Second Human Niagen® Study Shows Effectiveness

A 2017 research published in PLOS One followed the effects of Niagen® as the dosage was gradually increased. The study gave 250mg of Niagen® to eight healthy participants on Days 1 and 2, then gradually increased the dosages on each consecutive day. The trial delivered a peak dosage of 1000mg twice day on days 7 and 8. On Day 9, the research revealed that oral delivery of Niagen® was well tolerated in people with no side effects.

Third Human Niagen® Study Proves Effectiveness

A 2018 research published in the American Journal of Clinical Nutrition indicated that taking 2000mg of Niagen® daily for 12 weeks is safe. Furthermore, the individuals’ urine tests demonstrated an increase in NAD+ metabolites.

The Fourth Human Niagen® Study Shows Effectiveness

According to a 2018 research published in Nature Communications, Niagen® supplementation is well-tolerated and efficiently raises NAD+ in a sample of healthy middle-aged and older persons. The participants were 60 healthy men and women ranging in age from 55 to 79. The study used a randomized, placebo-controlled, crossover design and delivered 500mg twice day for six weeks.

The Fifth Human Niagen® Study Shows Effectiveness

A 2019 study published in Cell Reports looked at the effects of Niagen® on skeletal muscle. For 21 days, 12 mildly overweight older men were given 1000mg of Niagen® daily. The study found that “oral nicotinamide riboside raised human skeletal muscle NAAD, a sensitive measure of increased NAD+ metabolism.”

The Sixth Human Niagen® Study Shows Effectiveness

In 2020, The American Journal of Clinical Nutrition released a research that looked at the benefits of Niagen® on metabolic health, muscular metabolism, and mitochondrial function. The study included 13 healthy overweight and obese individuals in a randomized, double-blind, placebo-controlled crossover experiment. NR supplementation, like the prior study, dramatically elevated indicators of accelerated NAD+ metabolism in human skeletal muscle.

The Seventh Human Niagen® Study Shows Effectiveness

The Journal of Clinical Investigation published an ex vivo and pilot clinical investigation that looked into mitochondrial dysfunction in peripheral blood mononuclear cells (PBMCs). According to the findings, NR enhanced whole blood NAD+ levels as well as the mitochondrial respiration rate of PBMCs.

Nicotinamide riboside can enter cells directly. NMN cannot

Nicotinamide riboside reaches cells instantly after absorption, whereas NMN cannot. A series of published studies by some of the field’s finest experts show that NMN cannot enter cells directly; it must first be transformed to nicotinamide riboside.

For example, a research published in Nature Communications in 2016 on the metabolism of NMN in mammalian cells indicated that NMN cannot enter the cell directly.

With the exception of one phosphate group on NMN, nicotinamide riboside and NMN are chemically identical. The research shows that this extra phosphate group in NMN must be eliminated before it can enter the cell, turning it to nicotinamide riboside.

Similarly, because NAD+ is excessively big and includes numerous phosphate groups, it has no advantage over nicotinamide riboside supplementation.

Before entering the cell, NAD+ must be broken down into separate components, which are subsequently reformed into NAD+.However, a 2019 research published in Nature Metabolism claimed to have discovered an NMN transport protein in the small intestine of mice. However, academics Mark S. Schmidt and Charles Brenner questioned the veracity of this assertion, claiming a lack of evidence for this NMN transporter.

Niagen® carries the NSF Certified for Sport® certification, while none of the NMN products do

Tru Niagen®, ChromaDex’s nicotinamide riboside consumer product, carries the NSF Certified for Sport® designation.

The NSF Certified for Sport® seal confirms that Tru Niagen® is manufactured in accordance with current Good Manufacturing Practice (cGMP) standards, that the level of Niagen® in the product is consistent with the amount claimed on the label, and that it is free of over 270 athletic banned substances and harmful contaminants.

The absence of regulatory evaluation of NMN, on the other hand, hinders NMN goods from holding the NSF Certified for Sport® label.

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Tru Niagen Alternative

LIPO NAD+ Complete – Powdered Liposomal NAD+, NMN, & NR

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LIPO NAD+ CompleteTM contains Renue by science’s patented, powder-based liposomes formed of natural phospholipid molecules that shield NMN, NR, and NAD+ from digestive enzymes and transport them into the circulation for targeted systemic distribution.

All three in one pill to better treat all areas of the body that may benefit from NAD+ restoration.

The powdered liposomes technique of LIPO CAPS wraps nanosized particles in liposomes, which are subsequently freeze-dried to eliminate the aqueous phase. It’s similar to dehydrating grapes to make raisins, but liposomes re-inflate in the body.

This guarantees optimal bioavailability and stability, preventing degradation of the bio-active components.

This encapsulation method has been scientifically demonstrated to increase nutritional bioavailability through safety, absorption, and blood glucose testing.

A maximum particle size of less than 50 nm (nanometers) guarantees optimal bioavailability and stability.

The basic structure of the liposomal bilayer is preserved in the enhanced liposomes powder form, which stabilizes the active component and provides optimal bioefficiency, potency, and absorption.

In ALIVE BY SCIENCE  production process, we use natural non-hydrogenated sunflower phosphatidylcholine produced from non-GMO certified sunflower oil from Europe. During liposome production, it goes through a multi-step purification and filtering procedure to achieve maximum purity.

More about The Liposome Advantage

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PatchMD NAD Total Recovery Topical Patch 

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Apply the patch to a hairless area, such as the shoulder, back, or hip, on a regular basis. PatchMD patches should be worn for at least 8 hours for optimum benefits. Wearing the patch for more than 8 hours had no further benefits. Patches can be worn at night. Any lotion or cream applied to the same region will prevent absorption. The patch is not water resistant. It is OK to wear many patches at the same time.

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Life Extension NAD+ Cell Regenerator

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The best-selling book on life extension The NIAGEN® nicotinamide riboside formula enhances the generation of NAD+, a coenzyme that supports cellular metabolism and boosts cellular energy production.

The Benefits of NAD+ Cell Regenerator

  • Helps to maintain young levels of the cellular coenzyme NAD+, which is required for the generation of ATP, or cellular fuel.
  • Improves cellular metabolism and energy generation.
  • Aids in the prevention of general weariness and the promotion of lifespan
  • In preclinical trials, it promotes young cognitive performance.

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